(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

Base Information

Chemical Name:(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole
CAS No.:437768-39-3
Molecular Formula:C₁₃H₁₇N₅O₂
Molecular Weight:275.31
Hs Code.:

Synonyms:(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

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Chemical Property of (+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

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Technology Process of (+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

There total 5 articles about (+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78558-73-3
2-(tert-butoxycarbonylamino)-2-phenylacetonitrile

: 437768-39-3
(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

Guidance literature:: With sodium azide; zinc dibromide; In water; isopropyl alcohol; for 16h; Heating;
DOI:10.1021/ol020096x

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 437768-39-3
(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: TEA / tetrahydrofuran / 0.5 h / -10 °C

1.2: 90 percent / NH₃ / tetrahydrofuran / cooling

2.1: 100 percent / (CF₃CO)2O; TEA / tetrahydrofuran / 14 h / 20 °C

3.1: 83 percent / NaN₃; Et₃N*HCl / toluene / 16 h / 95 °C

With sodium azide; TEA; triethylamine hydrochloride; trifluoroacetic anhydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2006.09.095

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 437768-39-3
(+/-)-N-tert-butoxycarbonyl phenylglycine tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 67 percent / aq. NaOH / dioxane / 12 h / 20 °C

2.1: TEA / tetrahydrofuran / 0.5 h / -10 °C

2.2: 90 percent / NH₃ / tetrahydrofuran / cooling

3.1: 100 percent / (CF₃CO)2O; TEA / tetrahydrofuran / 14 h / 20 °C

4.1: 83 percent / NaN₃; Et₃N*HCl / toluene / 16 h / 95 °C

With sodium hydroxide; sodium azide; TEA; triethylamine hydrochloride; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1016/j.bmcl.2006.09.095