4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide

Base Information

• Chemical Name: 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide
• CAS No.: 107244-88-2
• Molecular Formula: C₂₂H₂₆ClN₃O₂
• Molecular Weight: 399.92

Synonyms:4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide

Chemical Property of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide

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Technology Process of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide

There total 6 articles about 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol N^ω oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4,7-dichloroquinoline 1-oxide (1077-74-3) + 4-amino-2-<(diethylamino)methyl>-6-ethylphenol (107244-71-3) → 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol Nω oxide (107244-88-2)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1021/jm00388a027

Reference yield:

o-Hydroxyethylbenzene (90-00-6) → 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol Nω oxide (107244-88-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 44 percent / aq. HCl, NaNO₂ / aq. ethanol / 5 h / 0 °C

2: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

3: methanol; tetrahydrofuran / 0.5 h / Heating

4: 60 percent / ethanol / 48 h / Heating

5: 89 percent / 6N aq. HCl / 1 h / Heating

6: 50 percent / ethanol / 2 h / Heating

With hydrogenchloride; hydrogen; sodium nitrite; nickel; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00388a027

Reference yield:

2-ethyl-4-(hydroxyimino)cyclohexa-2,5-dienone (107244-56-4) → 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-ethylphenol Nω oxide (107244-88-2)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Ni (Ra) / methanol / 5.5 h / 2663.3 Torr

2: methanol; tetrahydrofuran / 0.5 h / Heating

3: 60 percent / ethanol / 48 h / Heating

4: 89 percent / 6N aq. HCl / 1 h / Heating

5: 50 percent / ethanol / 2 h / Heating

With hydrogenchloride; hydrogen; nickel; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00388a027

upstream raw materials:

4,7-dichloroquinoline 1-oxide

4-amino-2-<(diethylamino)methyl>-6-ethylphenol

o-Hydroxyethylbenzene

2-ethyl-4-(hydroxyimino)cyclohexa-2,5-dienone

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