(2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine

Base Information

• Chemical Name: (2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine
• CAS No.: 338462-55-8
• Molecular Formula: C₁₉H₂₅NO₅
• Molecular Weight: 347.411
• Mol file: 338462-55-8.mol

Synonyms:(2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine

Chemical Property of (2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine

There total 1 articles about (2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyloxyacetyl chloride (19810-31-2) + ethyl (E)-4-(morpholin-4-yl)but-2-enoate → N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine + (2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine (338462-55-8)

Guidance literature:

With {Mg{1,2-bis[(oxazolin-2-yl)-4-(R)-(p-MeOPh)]-4,5-Cl₂}C₆H₂}I₂; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 ℃; for 12h; Title compound not separated from byproducts.;

DOI:10.1021/ja015612d

Reference yield:

(2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine (338462-55-8) → (2S,3R)-2-Benzyloxy-3-vinyl-succinic acid 4-ethyl ester

Guidance literature:

(2S,3R)-N-(2-benzyloxy-3-(ethoxycarbonyl)-4-pentenoyl)-morpholine; With iodine; In 1,2-dimethoxyethane; water; at 23 ℃; for 1h;

With acetic acid; zinc; In 1,2-dimethoxyethane; water; at 65 ℃; for 1.5h;

With hydrogenchloride; In 1,2-dimethoxyethane; water; at 20 ℃; Further stages.;

DOI:10.1021/ja015612d

upstream raw materials:

Benzyloxyacetyl chloride