[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

Base Information

Chemical Name:[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol
CAS No.:1307314-18-6
Molecular Formula:C₁₄H₁₈FN₃O
Molecular Weight:263.315
Hs Code.:

Synonyms:[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

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Chemical Property of [1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

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Technology Process of [1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

There total 4 articles about [1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1307314-17-5
ethyl 1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazole-4-carboxylate

: 1307314-18-6
[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm500117r

Reference yield:

: 1307314-16-4
ethyl 1-(2-fluoro-6-formylphenyl)-3-methylpyrazole-4-carboxylate

: 1307314-18-6
[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran / 0.17 h

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm500117r

Reference yield:

: 40704-11-8
3-methyl-1H-pyrazole-4-carboxylic acid

: 1307314-18-6
[1-[2-(dimethylaminomethyl)-6-fluorophenyl]-3-methylpyrazol-4-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 20 h / 85 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3.1: acetic acid / tetrahydrofuran / 0.17 h

3.2: 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm500117r