2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

• Chemical Name: 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
• CAS No.: 213548-38-0
• Molecular Formula: C₃₀H₄₆Cl₂N₂O₈Si₂
• Molecular Weight: 689.781

Synonyms:2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Chemical Property of 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Chemical Property:

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Technology Process of 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 2 articles about 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,5-dichlorobenzyl vinyl ether (213547-81-0) + 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (213548-38-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 6h;

DOI:10.1002/hlca.19980810557

Reference yield:

3,5-dichlorobenzyl alcohol (60211-57-6) → 2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (213548-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / mercury(II)trifluoroacetate / 1 h / Ambient temperature

2: 93 percent / TsOH / toluene / 6 h / 20 °C

With mercury(II) trifluoroacetate; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/hlca.19980810557

Reference yield: 79.0%

2'-O-[1-(3,5-dichlorobenzyloxy)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (213548-38-0) → 1-{(2R,3R,4R,5R)-3-[1-(3,5-Dichloro-benzyloxy)-ethoxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

Guidance literature:

With Bu₃NF*3H₂O; In 1,4-dioxane; Ambient temperature;

DOI:10.1002/hlca.19980810557

upstream raw materials:

3,5-dichlorobenzyl vinyl ether

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

3,5-dichlorobenzyl alcohol

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