5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

Base Information

Chemical Name:5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one
CAS No.:1447911-77-4
Molecular Formula:C₁₆H₁₇ClN₂O₃
Molecular Weight:320.776
Hs Code.:

Synonyms:5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

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Chemical Property of 5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

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Technology Process of 5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

There total 5 articles about 5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1008517-74-5
5-hydroxy-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

: 622-95-7
4-chlorobenzyl bromide

: 1447911-77-4
5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 16h;
DOI:10.1021/acs.jmedchem.5b01704

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1447911-77-4
5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 40 h / Reflux

2: potassium hydroxide / 19.5 h / 0 - 50 °C

3: potassium hydroxide / water / 3 h / Reflux

4: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01704

Reference yield:

: 173206-13-8
4,5-dichloro-2-(tetrahydro-2H-pyran-2-yl)-3(2H)-pyridazinone

: 1447911-77-4
5-((4-chlorobenzyl)oxy)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / 19.5 h / 0 - 50 °C

2: potassium hydroxide / water / 3 h / Reflux

3: triethylamine; palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01704