amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

Base Information

Chemical Name:amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate
CAS No.:1239957-15-3
Molecular Formula:C₂HF₃O₂*C₂₉H₂₉ClF₃N₅O₂S
Molecular Weight:718.12
Hs Code.:

amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

Synonyms:amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

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Chemical Property of amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

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Technology Process of amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

There total 14 articles about amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239963-55-3
tert-butyl (tert-butoxycarbonylamino)(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methylenecarbamate

: 76-05-1
trifluoroacetic acid

: 1239957-15-3
amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: tert-butyl (tert-butoxycarbonylamino)(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methylenecarbamate; With trifluoroacetic acid; In dichloromethane; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239957-15-3
amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1: sulfuric acid; water / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

7: acetic acid / 4 h / Reflux

8: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

9: hydrogen fluoride / acetonitrile / 1 h

10: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

11: trifluoroacetic acid / dichloromethane / 1 h

With hydrogenchloride; dmap; sodium azide; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen fluoride; water; hydrogen; tetra-N-butylammonium tribromide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1239963-78-0
2-(4-chloro-3-methoxyphenyl)-2-methylpropanoic acid

: 1239957-15-3
amino(2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethylamino)methaniminium 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

2: tetrahydrofuran / 2 h / -78 - 20 °C

3: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

5: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

6: acetic acid / 4 h / Reflux

7: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

8: hydrogen fluoride / acetonitrile / 1 h

9: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

10: trifluoroacetic acid / dichloromethane / 1 h

With hydrogenchloride; dmap; sodium azide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; tetra-N-butylammonium tribromide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;