4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril

Base Information

• Chemical Name: 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril
• CAS No.: 112556-90-8
• Molecular Formula: C₁₇H₁₅N₅O
• Molecular Weight: 305.339
• Mol file: 112556-90-8.mol

Synonyms:4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril

Chemical Property of 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril

There total 2 articles about 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

p-toluidine (106-49-0,12221-03-3) + 2-<(Dimethylaminomethylen)amino>-1-carbomethoxy-4-dimethylamino-1,3-butadien-1,3-dicarbonitril (112556-87-3) → 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril (112556-90-8)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 1.5h;

DOI:10.1007/BF00809673

Reference yield:

(Z)-3-Amino-2,4-dicyan-2-butensaeure-methylester (89500-75-4) → 4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril (112556-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / 0.5 h / Heating

2: 86 percent / dimethylformamide / 1.5 h / 120 °C

In N,N-dimethyl-formamide;

DOI:10.1007/BF00809673

Reference yield: 66.0%

4-<(Dimethylaminomethylen)amino>-1,2-dihydro-1-(4-methylphenyl)-2-oxo-3,5-pyridindicarbonitril (112556-90-8) → 3,4,6,7-Tetrahydro-6-(4-methylphenyl)-4,7-dioxo-pyrido<4,3-d>pyrimidin-8-carbonitril (112556-93-1)

Guidance literature:

With hydrogenchloride; for 0.5h; Heating;

DOI:10.1007/BF00809673

upstream raw materials:

p-toluidine

2-<(Dimethylaminomethylen)amino>-1-carbomethoxy-4-dimethylamino-1,3-butadien-1,3-dicarbonitril

(Z)-3-Amino-2,4-dicyan-2-butensaeure-methylester

Downstream raw materials:

3,4,6,7-Tetrahydro-6-(4-methylphenyl)-4,7-dioxo-pyrido<4,3-d>pyrimidin-8-carbonitril