1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

Base Information

Chemical Name:1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester
CAS No.:99619-31-5
Molecular Formula:C₂₂H₂₃NO₅S₂
Molecular Weight:445.56
Hs Code.:

Synonyms:1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

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Chemical Property of 1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

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Technology Process of 1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

There total 2 articles about 1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67593-10-6
1-tosyl-N,N-dimethyl-3-indoleglycolamide

: 99619-31-5
1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / 2,4,6-trimethylbenzoic acid / 1.) 110 - 125 deg C, 10 min, 2.) 130 - 140 deg C, 10 min, 3.) 210 deg C, 3 h

2: 72 percent / P₄S₁₀ / tetrahydrofuran / 6 h / Irradiation; ultrasonic irradiation

3: 2.) 2 N HCl / 1.) CH₂Cl₂, 0 - 20 deg C, 30 min, 2.) water, THF, 23 h

With hydrogenchloride; tetraphosphorus decasulfide; mesitylenecarboxylic acid; In tetrahydrofuran;
DOI:10.1021/jo00352a001

Reference yield:

: 67593-15-1
1-<(4-methylphenyl)sulfonyl>-3-<(N,N-dimethylcarbamyl)methyl>indole-2-acetic acid, methyl ester

: 99619-31-5
1-<(4-methylphenyl)sulfonyl>-2-<(carbomethoxy)-methyl>indole-3-thioacetic S-acid, methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / P₄S₁₀ / tetrahydrofuran / 6 h / Irradiation; ultrasonic irradiation

2: 2.) 2 N HCl / 1.) CH₂Cl₂, 0 - 20 deg C, 30 min, 2.) water, THF, 23 h

With hydrogenchloride; tetraphosphorus decasulfide; In tetrahydrofuran;
DOI:10.1021/jo00352a001