(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

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Chemical Name:(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid
CAS No.:1266120-51-7
Molecular Formula:C₂₇H₃₇NO₃
Molecular Weight:423.596
Hs Code.:

Synonyms:(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

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Chemical Property of (R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

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Technology Process of (R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

There total 8 articles about (R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266120-46-0
[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-acetaldehyde

: 1202245-51-9,953079-94-2
(R)-pyrrolidine-3-carboxylic acid hydrochloride

: 1266120-51-7
(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

Guidance literature:: (R)-pyrrolidine-3-carboxylic acid hydrochloride; With potassium carbonate; In methanol; for 0.25h;

[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-acetaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 8 ℃; for 2h;

Reference yield:

: 15231-91-1
6-bromo-naphthalen-2-ol

: 1266120-51-7
(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / butanone; tert-butyl alcohol / 0.17 h / 110 °C

1.2: 15 h / 110 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 °C

2.3: 5 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: potassium carbonate / methanol / 0.25 h

5.2: 2 h / 8 °C

With lithium aluminium tetrahydride; n-butyllithium; potassium carbonate; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; butanone; tert-butyl alcohol;

Reference yield:

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1266120-51-7
(R)-1-{2-[6-(4-tert-butyl-cyclohexyloxy)-naphthalen-2-yl]-ethyl}-pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 26 h / 0 - 30 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 °C

3.3: 5 h / 0 - 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

6.1: potassium carbonate / methanol / 0.25 h

6.2: 2 h / 8 °C

With lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; potassium carbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; toluene;