N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide
CAS No.:1309358-74-4
Molecular Formula:C₂₀H₁₄F₆N₄O
Molecular Weight:440.348
Hs Code.:

Synonyms:N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

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Chemical Property of N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

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Technology Process of N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

There total 2 articles about N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 501698-49-3
1-[3-(trifluoromethyl)-phenyl]cyclopropanecarbonyl chloride

: 438019-67-1
[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]amine

: 1309358-74-4
N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; at 20 - 75 ℃;
DOI:10.1021/ml2001517

Reference yield:

: 104173-41-3
1-(3-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid

: 1309358-74-4
N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]-1-[3-(trifluoromethyl)-phenyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Cooling with ice; Inert atmosphere

2: sodium hydrogencarbonate / acetonitrile / 20 - 75 °C

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; acetonitrile;
DOI:10.1021/ml2001517