Technology Process of 3-(4-methoxybenzyl)-6-(morpholin-4-yl)benzo[h]quinazolin-4(3H)-one
There total 7 articles about 3-(4-methoxybenzyl)-6-(morpholin-4-yl)benzo[h]quinazolin-4(3H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane;
at 90 - 100 ℃;
for 10h;
Inert atmosphere;
Schlenk technique;
DOI:10.1016/j.tet.2014.05.117
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 20 h / 0 - 20 °C
2.1: hydrogenchloride / 1,4-dioxane; water / 8 h / 90 °C
3.1: ammonium bicarbonate / 0.33 h / 200 °C / Sealed tube; Microwave irradiation
4.1: potassium carbonate / acetone / 0.5 h / 55 °C / Sealed tube; Microwave irradiation
4.2: 3.5 h / 25 - 55 °C / Sealed tube; Microwave irradiation
5.1: palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; potassium tert-butylate / 1,4-dioxane / 10 h / 90 - 100 °C / Inert atmosphere; Schlenk technique
With
hydrogenchloride; N-Bromosuccinimide; potassium tert-butylate; palladium diacetate; ammonium bicarbonate; potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;
In
1,4-dioxane; water; acetone; acetonitrile;
3.1: |Niementowski Quinazolone Synthesis / 5.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.tet.2014.05.117
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 2 h / -20 °C / Inert atmosphere
1.2: 2 h / -20 - 20 °C / Inert atmosphere
2.1: N-Bromosuccinimide / acetonitrile / 20 h / 0 - 20 °C
3.1: hydrogenchloride / 1,4-dioxane; water / 8 h / 90 °C
4.1: ammonium bicarbonate / 0.33 h / 200 °C / Sealed tube; Microwave irradiation
5.1: potassium carbonate / acetone / 0.5 h / 55 °C / Sealed tube; Microwave irradiation
5.2: 3.5 h / 25 - 55 °C / Sealed tube; Microwave irradiation
6.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / 1,4-dioxane / 10 h / 90 - 100 °C / Inert atmosphere; Schlenk technique
With
hydrogenchloride; N-Bromosuccinimide; potassium tert-butylate; tert.-butyl lithium; palladium diacetate; ammonium bicarbonate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; diethyl ether; water; acetone; acetonitrile; pentane;
4.1: |Niementowski Quinazolone Synthesis / 6.1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.tet.2014.05.117
