2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Base Information

Chemical Name:2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide
CAS No.:1356017-09-8
Molecular Formula:C₁₅H₁₂ClN₃O₃S
Molecular Weight:349.798
Hs Code.:

Synonyms:2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

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Chemical Property of 2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

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Technology Process of 2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

There total 6 articles about 2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356016-36-8
2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid

: 94790-37-1
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate

: 6315-89-5
3,4-dimethoxyaniline

: 1356017-09-8
2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

: 1356017-10-1
2-(Benzotriazol-1-yloxy)-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 85006-31-1
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

: 1356017-09-8
2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 0.25 h

1.2: 0.25 h / 70 °C

2.1: trichlorophosphate / 0.25 h / 180 °C / microwave

3.1: hydrogen; sodium acetate / 20% palladium hydroxide-activated charcoal / ethyl acetate; isopropyl alcohol / 2585.81 Torr

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

4.2: 0.5 h / 100 °C

5.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); aminosulfonic acid; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; tert-butyl alcohol;

Reference yield:

: 35265-81-7
7-methylthieno<3,2-d>pyrimidine-2,4-dione

: 1356017-09-8
2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid (3,4-dimethoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 0.25 h / 180 °C / microwave

2.1: hydrogen; sodium acetate / 20% palladium hydroxide-activated charcoal / ethyl acetate; isopropyl alcohol / 2585.81 Torr

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1 h / Reflux

3.2: 0.5 h / 100 °C

4.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 1 h

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); aminosulfonic acid; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; tetrachloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;