N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Base Information

Chemical Name:N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester
CAS No.:250249-15-1
Molecular Formula:C₄₀H₅₄ClN₃O₁₀Si
Molecular Weight:800.421
Hs Code.:

<i>N</i>-[bis-(4-methoxy-phenyl)-methyl]-2-[2-<i>tert</i>-butoxycarbonylamino-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Synonyms:N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Suppliers and Price of N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

There total 13 articles about N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 250249-14-0
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

: 250249-15-1
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: With sulfuryl dichloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 250249-15-1
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / Et₃N / CH₂Cl₂ / 5 h / 0 °C

2: LiOH; H₂O / tetrahydrofuran / 1 h / 0 °C

3: 65 percent / HOBt; EDC / tetrahydrofuran / 4 h / 0 °C

4: 75 percent / imidazole / dimethylformamide / 24 h / 25 °C

5: 99 percent / H₂ / 10 percent Pd(OH)2/C / ethanol / 16 h / 25 °C

6: 91 percent / SO₂Cl₂ / diethyl ether; CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; lithium hydroxide; sulfuryl dichloride; water; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis / 3: Acylation / 4: Etherification / 5: Hydrogenolysis / 6: Chlorination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

: 28252-50-8
N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH

: 250249-15-1
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-tert-butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / K₂CO₃ / dimethylformamide / 12 h / 25 °C

2: 99 percent / H₂ / 20 percent Pd(OH)2 / methanol / 1 h / 25 °C

3: 65 percent / HOBt; EDC / tetrahydrofuran / 4 h / 0 °C

4: 75 percent / imidazole / dimethylformamide / 24 h / 25 °C

5: 99 percent / H₂ / 10 percent Pd(OH)2/C / ethanol / 16 h / 25 °C

6: 91 percent / SO₂Cl₂ / diethyl ether; CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; sulfuryl dichloride; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrogenolysis / 3: Acylation / 4: Etherification / 5: Hydrogenolysis / 6: Chlorination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X