tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate
CAS No.:1001270-07-0
Molecular Formula:C₂₇H₃₅ClFN₅O₄
Molecular Weight:548.057
Hs Code.:

tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Synonyms:tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

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Chemical Property of tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

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Technology Process of tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

There total 14 articles about tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1001270-12-7
(R)-2-(tert-butoxycarbonyl)-3-(4-chloro-3-fluorophenyl)-propanoic acid

: (5R,7R)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-ol dihydrochloride

: 1001270-07-0
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 623935-92-2
ethyl (2R)-2-methyl-5-(propan-2-ylidene)cyclopentanecarboxylate

: 1001270-07-0
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: ozone / ethyl acetate / 3.5 h / -68 °C

1.2: 0.5 h / 0 °C

2.1: ammonium acetate / methanol / 20 h / 20 °C

3.1: 17 h / 150 °C

4.1: trichlorophosphate / 0.08 h / Heating / reflux

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

5.2: 0.33 h / 0 °C

6.1: 2 h / 110 °C

7.1: 1-methyl-pyrrolidin-2-one / 60 h / 125 °C

8.1: lithium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

10.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; lithium hydroxide; ammonium acetate; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; ethyl acetate;

Reference yield:

: 85440-74-0
(2R)-2-methyl-5-oxocyclopentanecarboxylic acid ethyl ester

: 1001270-07-0
tert-butyl (R)-3-(4-chloro-3-fluorophenyl)-1-((S)-4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide; ethanol / water / 10 h / Heating / reflux

1.2: 0 °C

2.1: ammonia; water / nickel / 3 h / Heating / reflux

3.1: trichlorophosphate / 0.08 h / Heating / reflux

4.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 48 h / 20 °C

4.2: 0.33 h / 0 °C

5.1: 2 h / 110 °C

6.1: 1-methyl-pyrrolidin-2-one / 60 h / 125 °C

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; potassium hydroxide; ethanol; ammonia; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; nickel; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform; water;