2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>

Base Information

• Chemical Name: 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>
• CAS No.: 226882-02-6
• Molecular Formula: C₅₂H₅₇N₆O₁₃P
• Molecular Weight: 1005.03

Synonyms:2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>

Chemical Property of 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>

Chemical Property:

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Technology Process of 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite>

There total 4 articles about 2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-O-methyl-5'-O-(monomethoxytrityl)-N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine (185761-14-2) + 2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidochloridite (226881-83-0) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> (226882-02-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

Reference yield:

2-(4-nitrophenyl)ethyl phosphorodichloridite (76101-32-1) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> (226882-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / diethyl ether / 1.) 0 deg C, 20 min; 2.) RT, 2 h

2: 90 percent / (iPr)2EtN / CH₂Cl₂ / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

Reference yield:

N-isopropylethylamine (19961-27-4) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N4-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidite> (226882-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / Mg, MeI / diethyl ether / 22.5 h / Heating

2: 98 percent / diethyl ether / 1.) 0 deg C, 20 min; 2.) RT, 2 h

3: 90 percent / (iPr)2EtN / CH₂Cl₂ / Ambient temperature

With magnesium; N-ethyl-N,N-diisopropylamine; methyl iodide; In diethyl ether; dichloromethane;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

upstream raw materials:

2'-O-methyl-5'-O-(monomethoxytrityl)-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine

2-(4-nitrophenyl)ethyl ethyl(isopropyl)phosphoramidochloridite

2-(4-nitrophenyl)ethyl phosphorodichloridite

N-isopropylethylamine

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