(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

Base Information

Chemical Name:(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid
CAS No.:1415322-34-7
Molecular Formula:C₃₂H₃₆N₂O₅
Molecular Weight:528.648
Hs Code.:

Synonyms:(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

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Chemical Property of (2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

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Technology Process of (2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

There total 6 articles about (2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415325-02-8
(S)-methyl 2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoate

: 1415322-34-7
(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

Guidance literature:: (S)-methyl 2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 873073-49-5
methyl 2(S)-2-[5-(bromomethyl)-2-chlorophenoxy]propionate

: 1415322-34-7
(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

2: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

With morpholine; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 108-39-4
3-methyl-phenol

: 1415322-34-7
(2S)-2-(3-((5-(((S)-1-(3-isopropoxyphenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)phenoxy)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 16 h / 80 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

4: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 20 °C

6: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

With morpholine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;