(4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone

Base Information

• Chemical Name: (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone
• CAS No.: 852181-20-5
• Molecular Formula: C₂₀H₂₀FNO₃
• Molecular Weight: 341.382
• Mol file: 852181-20-5.mol

Synonyms:(4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone

Chemical Property of (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone

There total 4 articles about (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-fluoro-4-methylphenyl)acrylic acid methyl ester (852181-16-9) → (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone (852181-20-5)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol

2: aq. NaOH / Heating

3: SOCl₂ / dimethylformamide / 1 h / Heating

4: n-BuLi; 1,10-phenanthroline / tetrahydrofuran; hexane / -78 °C

With sodium hydroxide; n-butyllithium; thionyl chloride; 1,10-Phenanthroline; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

DOI:10.3390/90600449

Reference yield:

(R)-4-(phenylmethyl)-2-oxazolidinone (40217-17-2,90719-32-7,120574-96-1,102029-44-7) + 3-(2-fluoro-4-methyl-phenyl)-propionyl chloride → (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone (852181-20-5)

Guidance literature:

With n-butyllithium; 1,10-Phenanthroline; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.3390/90600449

Reference yield:

3-(2-fluoro-4-methyl-phenyl)-propionic acid methyl ester → (4R)-4-benzyl-3-[3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone (852181-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH / Heating

2: SOCl₂ / dimethylformamide / 1 h / Heating

3: n-BuLi; 1,10-phenanthroline / tetrahydrofuran; hexane / -78 °C

With sodium hydroxide; n-butyllithium; thionyl chloride; 1,10-Phenanthroline; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.3390/90600449

upstream raw materials:

(R)-4-(phenylmethyl)-2-oxazolidinone

3-(2-fluoro-4-methylphenyl)acrylic acid methyl ester

3-(2-fluoro-4-methylphenyl)propionic acid

Downstream raw materials:

(4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2-fluoro-4-methylphenyl)propionyl]-2-oxazolidinone