2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

Base Information

Chemical Name:2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone
CAS No.:1447724-11-9
Molecular Formula:C₂₅H₂₃F₂N₇O₂
Molecular Weight:491.5
Hs Code.:

Synonyms:2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

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Chemical Property of 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

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Technology Process of 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

There total 7 articles about 2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443257-42-8
(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid

: 1439303-84-0
5-methoxy-2-(piperazin-1-yl)pyrimidine hydrochloride

: 1447724-11-9
2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

Guidance literature:: (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid; With N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.116667h;

5-methoxy-2-(piperazin-1-yl)pyrimidine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1038410-94-4
3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole

: 1447724-11-9
2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / 24 h / Reflux

2.1: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

3.1: pentafluorophenol-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.12 h / 20 °C

3.2: 3 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1443257-13-3
(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester

: 1447724-11-9
2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(5-methoxy-pyrimidin-2-yl)-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

2.1: pentafluorophenol-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.12 h / 20 °C

2.2: 3 h / 20 °C

With N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;