2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Base Information

Chemical Name:2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide
CAS No.:368426-49-7
Molecular Formula:C₂₈H₂₉N₅O₆S
Molecular Weight:563.634
Hs Code.:

2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[<i>b</i>]azepin-1-yl]-<i>N</i>-[4-(<i>N</i>-hydroxycarbamimidoyl)-benzyl]-acetamide

Synonyms:2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

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Chemical Property of 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

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Technology Process of 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

There total 15 articles about 2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 433717-68-1
N-(4-cyano-benzyl)-2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetamide

: 368426-49-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: With 4-methyl-morpholine; hydroxylamine hydrochloride; In methanol; at 20 ℃; for 10h;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 4424-80-0
2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

: 368426-49-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: TMEDA; NaI / acetonitrile / -5 °C

2.1: 95 percent / I₂ / -5 - 20 °C

3.1: NH₃ / aq. ethanol / 0 - 20 °C

3.2: L-pyroglutamic acid; 5-NO₂-salicylaldehyde / propan-2-ol; H₂O / 48 h / 70 °C

4.1: 99 percent / Na₂CO₃ / dioxane; H₂O / 18 h / 20 °C

5.1: LiHMDS / tetrahydrofuran / 0 °C

5.2: tetrahydrofuran / 0 - 20 °C

6.1: 100 percent / HCl / ethyl acetate / 0 - 20 °C

7.1: 57 percent / NMM / dimethylformamide / 20 °C

8.1: 97 percent / H₂ / Pd/C / methanol / 3 h / 2327.17 Torr

9.1: 83 percent / EDC; HOBt; NMM / dimethylformamide

10.1: 51 percent / NH₂OH*HCl; NMM / methanol / 10 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; ammonia; hydrogen; iodine; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3.2: racemate resolution;
DOI:10.1016/S0960-894X(02)00010-0

Reference yield:

: 3349-64-2,68253-36-1,100485-58-3
1-tetralone oxime

: 368426-49-7
2-[3-(2,3-dihydro-benzofuran-5-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-N-[4-(N-hydroxycarbamimidoyl)-benzyl]-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: PPA / 0.08 h / 115 °C

2.1: TMEDA; NaI / acetonitrile / -5 °C

3.1: 95 percent / I₂ / -5 - 20 °C

4.1: NH₃ / aq. ethanol / 0 - 20 °C

4.2: L-pyroglutamic acid; 5-NO₂-salicylaldehyde / propan-2-ol; H₂O / 48 h / 70 °C

5.1: 99 percent / Na₂CO₃ / dioxane; H₂O / 18 h / 20 °C

6.1: LiHMDS / tetrahydrofuran / 0 °C

6.2: tetrahydrofuran / 0 - 20 °C

7.1: 100 percent / HCl / ethyl acetate / 0 - 20 °C

8.1: 57 percent / NMM / dimethylformamide / 20 °C

9.1: 97 percent / H₂ / Pd/C / methanol / 3 h / 2327.17 Torr

10.1: 83 percent / EDC; HOBt; NMM / dimethylformamide

11.1: 51 percent / NH₂OH*HCl; NMM / methanol / 10 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; ammonia; hydrogen; iodine; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 4.2: racemate resolution;
DOI:10.1016/S0960-894X(02)00010-0