3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1100768-27-1
Molecular Formula:C₂₉H₃₆F₃N₅O₅
Molecular Weight:591.631
Hs Code.:

Synonyms:3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 7 articles about 3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1100768-26-0
3-[4-(1-amino-ethyl)-2-trifluoromethyl-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester

: 1100767-27-8
N-(4-carbamimidoyl-phenyl)-malonamic acid trifluoroacetate

: 1100768-27-1
3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 113117-17-2
ethyl 3-[(4-cyanophenyl)amino]-3-oxopropanoate

: 1100768-27-1
3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 20 h / 20 °C

2.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

2.2: 4 h / 20 °C

3.1: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; hydroxylamine hydrochloride; ammonium formate; triethylamine; palladium 10% on activated carbon; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1100767-24-5
N-[4-(N-hydroxycarbamimidoyl)-phenyl]-malonamic acid ethyl ester

: 1100768-27-1
3-(4-{1-[2-(4-carbamimidoyl-phenylcarbamoyl)-acetylamino]-ethyl}-2-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / acetic acid / 5 h / Heating / reflux

1.2: 4 h / 20 °C

2.1: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; ammonium formate; palladium 10% on activated carbon; In acetic acid; N,N-dimethyl-formamide;