Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

Base Information

Chemical Name:Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester
CAS No.:135366-28-8
Molecular Formula:C₃₄H₃₉F₃N₂O₉
Molecular Weight:676.687
Hs Code.:

Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

Synonyms:Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

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Chemical Property of Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

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Technology Process of Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

There total 10 articles about Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135366-27-7
(1S,6S)-1-Hydroxy-6-[(S)-hydroxy-(2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl]-7,9-bis-(4-methoxy-benzyl)-2-methylene-7,9-diaza-bicyclo[4.2.2]decane-8,10-dione

: 407-25-0
trifluoroacetic anhydride

: 135366-28-8
Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

Guidance literature:: With dmap; In dichloromethane; at 0 ℃; for 0.666667h;

Reference yield:

: 135366-10-8,135416-39-6
(Z)-1,4-bis(p-methoxybenzyl)-3-(6'-hydroxy-4'-hexenyl)-6-methoxy-2,5-piperazinedione

: 135366-28-8
Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 37 percent / p-toluenesulfonic acid, pyridinium p-toluenesulfonate / CH₂Cl₂ / 70 h / Heating

3: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.67 h

4: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, methanol, RT, 7 h

5: 1.) triethylamine, methanesulfonyl chloride, 2.) NaBH₄ / 1.) THF, 0 deg C, 1 h, 2.) CH₂Cl₂, ethanol, 80 deg C, 3 h

6: 30percent H₂O₂ / tetrahydrofuran / 0.5 h / Heating

7: 1.) n-butyllithium, TMEDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 20 min

8: 99.9 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature

9: 4-dimethylaminopyridine / CH₂Cl₂ / 0.67 h / 0 °C

With 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; ozone; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 135366-11-9
(Z)-11,13-bis(p-methoxybenzyl)-11,13-diaza-2-oxabicyclo<7.2.2>tridec-4-ene-10,12-dione

: 135366-28-8
Trifluoro-acetic acid (R)-[(1R,6R)-6-hydroxy-7,9-bis-(4-methoxy-benzyl)-5-methylene-8,10-dioxo-7,9-diaza-bicyclo[4.2.2]dec-1-yl]-((S)-2,2,4-trimethyl-[1,3]dioxolan-4-yl)-methyl ester

Guidance literature:: Multi-step reaction with 8 steps

2: 90 percent / 2,6-lutidine / CH₂Cl₂ / 0.67 h

3: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, methanol, RT, 7 h

4: 1.) triethylamine, methanesulfonyl chloride, 2.) NaBH₄ / 1.) THF, 0 deg C, 1 h, 2.) CH₂Cl₂, ethanol, 80 deg C, 3 h

5: 30percent H₂O₂ / tetrahydrofuran / 0.5 h / Heating

6: 1.) n-butyllithium, TMEDA / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 20 min

7: 99.9 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature

8: 4-dimethylaminopyridine / CH₂Cl₂ / 0.67 h / 0 °C

With 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; dihydrogen peroxide; ozone; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;