5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

Base Information

Chemical Name:5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile
CAS No.:1574394-61-8
Molecular Formula:C₁₅H₁₅ClN₄O₂
Molecular Weight:318.763
Hs Code.:

Synonyms:5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

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Chemical Property of 5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

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Technology Process of 5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

There total 3 articles about 5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1352943-58-8
2-isobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1574394-83-4
2-amino-5-chloro-6-iodopyrimidin-4-ol

: 1574394-61-8
5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.01.050

Reference yield:

: 876918-26-2
5-bromo-2-isobutoxy-benzonitrile

: 1574394-61-8
5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere

2: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenylphosphine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; triphenylphosphine; In N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.01.050

Reference yield:

: 40530-18-5
5-bromo-2-hydroxybenzonitrile

: 1574394-61-8
5-(2-amino-5-chloro-6-oxo-1,6-dihydropyrimidin-4-yl)2-isobutoxybenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 85 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere

3: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenylphosphine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.01.050