3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

Base Information

Chemical Name:3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol
CAS No.:811867-93-3
Molecular Formula:C₅₄H₆₄O₁₄
Molecular Weight:937.094
Hs Code.:

3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5<i>H</i>-tribenzo[<i>a</i>,<i>d</i>,<i>g</i>]cyclononen-2-ol

Synonyms:3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

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Chemical Property of 3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

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Technology Process of 3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

There total 5 articles about 3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 811867-92-2
C₅₇H₆₈O₁₄

: 811867-93-3
3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; In dichloromethane; at 23 ℃; for 1.5h;
DOI:10.1021/ja0483037

Reference yield: 72.0%

: 710338-24-2
7,12-bis[2-(4-hydroxymethyl-2-methoxyphenoxy)ethoxy]-3,8,13-trimethoxy-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

: 110-87-2
3,4-dihydro-2H-pyran

: 811867-93-3
3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

Guidance literature:: With pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/acs.joc.5b00653

Reference yield:

: 86534-12-5,123805-89-0,123805-90-3
(±)-2,7,12-trimethoxy-3,8,13-tris(2-propenyloxy)-10,15-dihydro-5Htribenzo[a,d,g]cyclononene

: 811867-93-3
3,8,13-trimethoxy-7,12-bis-{2-[2-methoxy-4-(tetrahydro-pyran-2-yloxymethyl)-phenoxy]-ethoxy}-10,15-dihydro-5H-tribenzo[a,d,g]cyclononen-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 26 percent / Pd(PPh₃)4; n-Bu₃SnH / CH₂Cl₂ / 1.5 h / 23 °C

2: 67 percent Turnov_. / Cs₂CO₃ / dimethylformamide / 2 h / 80 °C

3: 81 percent / K₂CO₃; n-Bu₄NI / dimethylformamide / 8 h / 80 °C

4: 89 percent / Pd(PPh₃)4; n-Bu₃SnH / CH₂Cl₂ / 1.5 h / 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja0483037