(5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane

Base Information

• Chemical Name: (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane
• CAS No.: 553611-71-5
• Molecular Formula: C₁₄H₂₃N₃O₂Si
• Molecular Weight: 293.441
• Mol file: 553611-71-5.mol

Synonyms:(5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane

Chemical Property of (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane

There total 1 articles about (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol (97315-19-0) → (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane (553611-71-5)

Guidance literature:

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.07.032

Reference yield: 85.0%

(5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane (553611-71-5) → 5-(azidomethyl)-2-methoxyphenol

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2010.07.032

Reference yield: 84.0%

3,4,5-trimethoxyphenylacetylene (53560-33-1) + (5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane (553611-71-5) → 1-(3-(tert-butyldimethylsilyloxy)-4-methoxybenzyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

Guidance literature:

3,4,5-trimethoxyphenylacetylene; With ethylmagnesium chloride; In tetrahydrofuran; at 20 - 50 ℃; Inert atmosphere;

(5-(azidomethyl)-2-methoxyphenoxy)(tert-butyl)dimethylsilane; In tetrahydrofuran; at 20 - 50 ℃;

DOI:10.1016/j.bmc.2010.07.032

upstream raw materials:

3-<(tert-butyldimethylsilyl)oxy>-4-methoxybenzyl alkohol