Technology Process of cis/trans-rac-5-(3-aminophenyl)-2,5-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
There total 7 articles about cis/trans-rac-5-(3-aminophenyl)-2,5-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
cis/trans-rac-5-(3-bromophenyl)-2,5-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine;
With
Benzophenone imine; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0);
In
toluene;
at 80 ℃;
for 2h;
Sealed tube;
Inert atmosphere;
With
hydrogenchloride; water;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
sodium carbonate;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride / 96 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C
3.2: 2 h / 0 °C
4.1: tetraphosphorus decasulfide / tetrahydrofuran / 3 h / 20 - 50 °C
5.1: ammonia / water; methanol / 6 h / 60 °C / Sealed tube
6.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 2 h / 80 °C / Sealed tube; Inert atmosphere
6.2: 1 h / 20 °C
With
hydrogenchloride; Benzophenone imine; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; methanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C
2.1: hydrogenchloride / 96 h / Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / -78 °C
4.2: 2 h / 0 °C
5.1: tetraphosphorus decasulfide / tetrahydrofuran / 3 h / 20 - 50 °C
6.1: ammonia / water; methanol / 6 h / 60 °C / Sealed tube
7.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0) / toluene / 2 h / 80 °C / Sealed tube; Inert atmosphere
7.2: 1 h / 20 °C
With
hydrogenchloride; Benzophenone imine; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; methanol; ammonia; water; toluene;
![cis/trans-rac-5-(3-bromophenyl)-2,5-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine](/Databaselist/images/loading.webp)
