3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione

Base Information

Chemical Name:3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione
CAS No.:83417-11-2
Molecular Formula:C₁₃H₁₆N₂O₂
Molecular Weight:232.282
Hs Code.:
UNII:QX04QC4IHW
ChEMBL ID:CHEMBL151032
Mol file:83417-11-2.mol

Synonyms:83417-11-2;3-Aminoglutethimide;3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione;QX04QC4IHW;AMINOGLUTETHIMIDE IMPURITY A;UNII-QX04QC4IHW;3-(3-Aminophenyl)-3-ethyl-2,6-piperidinedione;Aminoglutethimide impurity A [EP];2,6-Piperidinedione, 3-(3-aminophenyl)-3-ethyl-;m-Aminoglutethimide;CHEMBL151032;AMINOGLUTETHIMIDE IMPURITY A [EP IMPURITY]

Suppliers and Price of 3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
m-Aminoglutethimide
25mg
$ 835.00

TRC
m-Aminoglutethimide
50mg
$ 1470.00

Sigma-Aldrich
Aminoglutethimide impurity A
100mg
$ 1140.00

Sigma-Aldrich
Aminoglutethimide impurity A European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Aminoglutethimide impurity A European Pharmacopoeia (EP) Reference Standard
a0496005
$ 190.00

Total 0 raw suppliers

Chemical Property of 3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:232.121177757
Heavy Atom Count:17
Complexity:329

Purity/Quality:: m-Aminoglutethimide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1(CCC(=O)NC1=O)C2=CC(=CC=C2)N
Uses m-Aminoglutethimide is an aromatase inhibitor. Also blocks adrenal steroidogenesis.

Technology Process of 3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione

There total 2 articles about 3-(3-Aminophenyl)-3-ethylpiperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 73252-00-3
3-ethyl-3-(3'-nitrophenyl)piperidine-2,6-dione

: 83417-11-2
3-(3-aminophenyl)-3-ethylpiperidine-2,6-dione

Guidance literature:: With cyclohexene; palladium on activated charcoal; In 1,4-dioxane; for 3h; Heating;
DOI:10.1021/jm00355a011

Reference yield:

: 77-21-4,17575-58-5,17575-59-6,18389-24-7
Glutethimide

: 83417-11-2
3-(3-aminophenyl)-3-ethylpiperidine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 0.2 g / 70percent HNO₃ / 1 h / Heating

2: 67 percent / cyclohexene / 10percent Pd/C / dioxane / 3 h / Heating

With nitric acid; cyclohexene; palladium on activated charcoal; In 1,4-dioxane;
DOI:10.1021/jm00355a011