3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

Base Information

Chemical Name:3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester
CAS No.:884336-87-2
Molecular Formula:C₂₁H₂₅NO₆
Molecular Weight:387.433
Hs Code.:

Synonyms:3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

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Chemical Property of 3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

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Technology Process of 3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

There total 7 articles about 3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884336-92-9
4-(2-tert-butoxycarbonyl-ethyl)-5-formyl-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

: 884336-87-2
3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

Guidance literature:: With potassium permanganate; In acetone; at 20 ℃; for 1h;
DOI:10.1055/s-2005-918435

Reference yield:

: 852160-79-3
4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid benzyl ester

: 884336-87-2
3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

2: 960 mg / 2-methyl-propan-2-ol / 2 h / 40 °C

3: SO₂Cl₂; K₂CO₃ / diethyl ether / 2 h / 0 °C

4: H₂O / 0.5 h / 20 °C

5: 2.45 g / aq. KMnO₄ / acetone / 1 h / 20 °C

With potassium permanganate; sulfuryl dichloride; oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1055/s-2005-918435

Reference yield:

: 4-(2-chlorocarbonyl-ethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid benzyl ester

: 884336-87-2
3-(2-tert-butoxycarbonylethyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 960 mg / 2-methyl-propan-2-ol / 2 h / 40 °C

2: SO₂Cl₂; K₂CO₃ / diethyl ether / 2 h / 0 °C

3: H₂O / 0.5 h / 20 °C

4: 2.45 g / aq. KMnO₄ / acetone / 1 h / 20 °C

With potassium permanganate; sulfuryl dichloride; water; potassium carbonate; In diethyl ether; acetone; tert-butyl alcohol;
DOI:10.1055/s-2005-918435