(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

Base Information

Chemical Name:(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide
CAS No.:1312891-41-0
Molecular Formula:C₂₄H₂₇F₂N₃O₂
Molecular Weight:427.494
Hs Code.:

Synonyms:(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

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Chemical Property of (E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

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Technology Process of (E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

There total 3 articles about (E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1312891-75-0
(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylic acid methyl ester

: 1312891-41-0
(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

Guidance literature:: With hydroxylamine; sodium methylate; In methanol; water; at 0 ℃;
DOI:10.1021/jm200388e

Reference yield:

: 7560-50-1,71093-79-3,58045-41-3
methyl (2E)-3-(4-formylphenyl)acrylate

: 1312891-41-0
(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: SiliaBond cyanoborohydride / 0.25 h / 20 °C / Microwave irradiation; Heating

2.1: sodium hydrogencarbonate / tetrahydrofuran / 48 h / 20 °C

3.1: hydroxylamine; sodium methylate / methanol; water / 0 °C

With hydroxylamine; sodium methylate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200388e

Reference yield:

: 1312891-71-6
(E)-3-{4-[(3,3-difluoropropylamino)methyl]phenyl}acrylic acid methyl ester

: 54765-13-8
2-(2-methyl-1H-indol-3-yl)acetaldehyde

: 1312891-41-0
(E)-3-[4-({(3,3-difluoropropyl)[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]-N-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 48 h / 20 °C

2: hydroxylamine; sodium methylate / methanol; water / 0 °C

With hydroxylamine; sodium methylate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm200388e