N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide

Base Information

• Chemical Name: N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide
• CAS No.: 1130593-46-2
• Molecular Formula: C₂₅H₃₅N₃O₄
• Molecular Weight: 441.571

Synonyms:N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide

Chemical Property of N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide

Chemical Property:

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Technology Process of N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide

There total 1 articles about N₂,N₆-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-N,N'-bis[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]pyridine-2,6-dicarboxamide (1009339-34-7) + phenylboronic acid (98-80-6) → N2,N6-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide (1130593-46-2)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; acetonitrile; at 100 ℃; for 24h; Inert atmosphere;

Reference yield: 58.0%

N2,N6-bis((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-phenylpyridine-2,6-dicarboxamide (1130593-46-2) → (4S,4'S)-2,2'-(4-phenylpyridine-2,6-diyl)bis(4-tert-butyl-4,5-dihydrooxazole) (1130593-52-0)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -20 ℃; for 24h; Inert atmosphere;

upstream raw materials:

4-chloro-N,N'-bis[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]pyridine-2,6-dicarboxamide

phenylboronic acid

Downstream raw materials:

(4S,4'S)-2,2'-(4-phenylpyridine-2,6-diyl)bis(4-tert-butyl-4,5-dihydrooxazole)

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