benzyl (4S,7S)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Base Information

Chemical Name:benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate
CAS No.:102136-55-0
Molecular Formula:C₂₂H₂₂N₂O₆
Molecular Weight:410.426
Hs Code.:

Synonyms:benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

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Chemical Property of benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

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Technology Process of benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

There total 4 articles about benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 102115-98-0
(3S*,6S*)-6-<(amino)methyl>-2,3-bis(benzyloxycarbonyl)perhydro-1,2-oxazine-6-carboxylic acid

: 102136-55-0
benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: With 2,2'-dipyridyldisulphide; triphenylphosphine; In acetonitrile; at 80 ℃; for 2h;
DOI:10.1039/c39850001549

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 102136-55-0
benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / pyridine / CH₂Cl₂ / 25 °C

2: 99 percent / 98percent formic acid / 3 h / 25 °C

3: 63 percent / Ph₃P, di-2-pyridyl disulphide / acetonitrile / 2 h / 80 °C

With pyridine; formic acid; 2,2'-dipyridyldisulphide; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1039/c39850001549

Reference yield:

: 102115-96-8
(3S*,6S*)-2-benzyloxycarbonyl-6-<<(tert-butoxycarbonyl)amino>methyl>perhydro-1,2-oxazine-3,6-dicarboxylic acid

: 102136-55-0
benzyl (4S*,7S*)-6-benzyloxycarbonyl-1-oxo-5-oxa-2,6-diazaspiro<3.5>nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / pyridine / CH₂Cl₂ / 25 °C

2: 99 percent / 98percent formic acid / 3 h / 25 °C

3: 63 percent / Ph₃P, di-2-pyridyl disulphide / acetonitrile / 2 h / 80 °C

With pyridine; formic acid; 2,2'-dipyridyldisulphide; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1039/c39850001549