N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Base Information

Chemical Name:N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea
CAS No.:1301134-18-8
Molecular Formula:C₃₄H₃₀N₈O₂
Molecular Weight:582.665
Hs Code.:

Synonyms:N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Suppliers and Price of N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

There total 11 articles about N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301138-40-8
C₂₇H₂₅N₇O

: 103-71-9
phenyl isocyanate

: 1301134-18-8
N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1301134-18-8
N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / ethanol / 4 h / 20 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 27 h / 110 °C

3.2: 16 h / 20 °C

4.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C

5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 82 h / 90 °C

6.1: water; ammonium chloride; iron / ethanol / 2.5 h / 90 °C

7.1: tetrahydrofuran / 16 h / 20 °C

With N-iodo-succinimide; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 34658-67-8
2-(3-nitrophenyl)imidazo[1,2-a]pyridine

: 1301134-18-8
N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N'-phenylurea

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 27 h / 110 °C

2.2: 16 h / 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 82 h / 90 °C

5.1: water; ammonium chloride; iron / ethanol / 2.5 h / 90 °C

6.1: tetrahydrofuran / 16 h / 20 °C

With N-iodo-succinimide; water; iron; potassium carbonate; ammonium chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;