Technology Process of 7-((4-fluorobenzyl)carbamoyl)-8-hydroxyquinoline 1-oxide
There total 6 articles about 7-((4-fluorobenzyl)carbamoyl)-8-hydroxyquinoline 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; trifluoroacetic acid;
In
water;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere
2: hydrogenchloride; acetic acid / 120 h / 20 °C
3: trifluoroacetic acid; dihydrogen peroxide / water / 80 °C
With
hydrogenchloride; dihydrogen peroxide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / Reflux; Inert atmosphere
2: sodium hydroxide; water / methanol / 20 °C / Inert atmosphere
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere
4: hydrogenchloride; acetic acid / 120 h / 20 °C
5: trifluoroacetic acid; dihydrogen peroxide / water / 80 °C
With
hydrogenchloride; water; dihydrogen peroxide; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
