3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide
CAS No.:1401937-58-3
Molecular Formula:C₂₈H₃₄INO₂
Molecular Weight:543.488
Hs Code.:

Synonyms:3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

There total 14 articles about 3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1318265-18-7
3-{[(16β,17β)-3-(2-bromoethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

: 1401937-58-3
3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: With sodium iodide; In acetone; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 1318265-22-3
3-(2-hydroxyethyl)estra-1⁽¹⁰⁾,2,4-trien-17-dioxolane

: 1401937-58-3
3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 20 °C

1.3: 5 h / 20 °C

2.1: potassium hydroxide; water / ethanol / 0.5 h / Reflux

3.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h / 20 °C

3.2: 36 h

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.67 h / 0 °C

5.1: sodium iodide / acetone / 48 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; carbon tetrabromide; water; sodium hydride; triphenylphosphine; sodium iodide; potassium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 1318265-23-4
3-[2-(benzyloxy)ethyl]estra-1⁽¹⁰⁾,2,4-trien-17-one

: 1401937-58-3
3-{[(16β,17β)-17-hydroxy-3-(2-iodoethyl)estra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / ethanol / 0.5 h / Reflux

2.1: sodium tetrahydroborate; methanol / dichloromethane / 1 h / 20 °C

2.2: 36 h

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.67 h / 0 °C

4.1: sodium iodide / acetone / 48 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; carbon tetrabromide; water; triphenylphosphine; sodium iodide; potassium hydroxide; In ethanol; dichloromethane; acetone;