[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

Base Information

Chemical Name:[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone
CAS No.:279693-85-5
Molecular Formula:C₂₃H₃₂N₂O₄
Molecular Weight:400.518
Hs Code.:

[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1<i>H</i>-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

Synonyms:[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

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Chemical Property of [5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

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Technology Process of [5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

There total 5 articles about [5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 279693-84-4
2,5-dimethyl-4-methoxybenzoyl chloride

: 253772-35-9
4-bromo-2-ethyl-1-(1-methylbutyl)imidazole-5-carboxaldehyde ethylene glycol acetal

: 279693-85-5
[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

Guidance literature:: 4-bromo-2-ethyl-1-(1-methylbutyl)imidazole-5-carboxaldehyde ethylene glycol acetal; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;

2,5-dimethyl-4-methoxybenzoyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Reference yield:

: 1072-62-4
2-Ethylimidazole

: 279693-85-5
[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / KHCO₃; Br₂ / dimethylformamide / 4 h / 70 °C

2.1: 41.5 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 59 percent / tetrahydrofuran; hexane / 1 h / -78 °C

4.1: 96 percent / pyridine; p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

5.1: n-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

5.2: 38 percent / tetrahydrofuran; hexane / -78 - 20 °C

With pyridine; n-butyllithium; di-isopropyl azodicarboxylate; bromine; potassium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene; 2.1: Mitsunobu reaction;

Reference yield:

: 4002-82-8
4,5-dibromo-2-ethyl-1H-imidazole

: 279693-85-5
[5-[1,3]dioxolan-2-yl-2-ethyl-1-(1-methyl-butyl)-1H-imidazol-4-yl]-(4-methoxy-2,5-dimethyl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 41.5 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 59 percent / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: 96 percent / pyridine; p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

4.1: n-BuLi / tetrahydrofuran; hexane / 2.5 h / -78 °C

4.2: 38 percent / tetrahydrofuran; hexane / -78 - 20 °C

With pyridine; n-butyllithium; di-isopropyl azodicarboxylate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; hexane; benzene; 1.1: Mitsunobu reaction;