(2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one

Base Information

• Chemical Name: (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one
• CAS No.: 146405-79-0
• Molecular Formula: C₂₅H₃₇NO₃S₂
• Molecular Weight: 463.706

Synonyms:(2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one

Chemical Property of (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one

There total 3 articles about (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophenol (108-98-5) + (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-oct-2-en-1-one → (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one (146405-79-0)

Guidance literature:

With lithium thiophenoxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1248/cpb.40.2579

Reference yield:

(+)-camphorsultam (108448-77-7,124224-04-0) → (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one (146405-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH

2: PhSLi / tetrahydrofuran / 0 °C

With lithium thiophenoxide; sodium hydride; In tetrahydrofuran;

DOI:10.1248/cpb.40.2579

Reference yield:

β-(n-pentyl)methacryloyl chloride (303142-78-1) → (2S,3S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-2-methyl-3-phenylsulfanyl-octan-1-one (146405-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH

2: PhSLi / tetrahydrofuran / 0 °C

With lithium thiophenoxide; sodium hydride; In tetrahydrofuran;

DOI:10.1248/cpb.40.2579

upstream raw materials:

thiophenol

(+)-camphorsultam

β-(n-pentyl)methacryloyl chloride

Downstream raw materials:

(2R,3S)-2-Methyl-3-phenylsulfanyl-octanethioic acid S-benzyl ester

(3S,4S)-1-Diazo-3-methyl-4-phenylsulfanyl-nonan-2-one

(3S,4S)-3-Methyl-4-phenylsulfanyl-nonanoic acid

(2R,3S)-2-Methyl-3-phenylsulfanyl-octanoyl chloride

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