2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Base Information

Chemical Name:2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone
CAS No.:1380427-55-3
Molecular Formula:C₂₄H₂₃ClF₃N₃O₂S
Molecular Weight:509.98
Hs Code.:

Synonyms:2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Suppliers and Price of 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

There total 7 articles about 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.7%

: 110-89-4
piperidine

: 1380429-73-1
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(hydroxymethyl)-4(1H)-pyrimidinone

: 1380427-55-3
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In N,N-dimethyl-formamide; at 45 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 516481-95-1
4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde

: 1380427-55-3
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium tetrahydroborate / 20 °C

2: thionyl chloride / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation

4: dimethylsulfide borane complex / tetrahydrofuran; toluene / 1.5 h / 0 - 20 °C / Inert atmosphere

5: di-isopropyl azodicarboxylate; triphenylphosphine / N,N-dimethyl-formamide / 0.5 h / 45 °C / Inert atmosphere; Microwave irradiation

With methanol; sodium tetrahydroborate; thionyl chloride; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1369255-78-6
1-chloro-4-(4-(chloromethyl)phenoxy)-2-(trifluoromethyl)benzene

: 1380427-55-3
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-(1-piperidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C / Microwave irradiation

2: dimethylsulfide borane complex / tetrahydrofuran; toluene / 1.5 h / 0 - 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / N,N-dimethyl-formamide / 0.5 h / 45 °C / Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; dimethylsulfide borane complex; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;