Technology Process of 8-acetyl-2,2-difluoro-4-{[3-(1H-imidazol-1-yl)phenyl]methyl}-2H-1,4-benzoxazin-3(4H)-one
There total 8 articles about 8-acetyl-2,2-difluoro-4-{[3-(1H-imidazol-1-yl)phenyl]methyl}-2H-1,4-benzoxazin-3(4H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(I) oxide;
In
methanol;
at 80 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / ethyl acetate / 2 h / 90 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C
3.1: n-butyllithium / diethyl ether / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C
3.3: pH 7
4.1: potassium carbonate / acetonitrile / 5 h / 20 °C
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere
6.1: hydrogenchloride; water; phenylboronic acid / 16 h / 80 °C
7.1: copper(I) oxide / methanol / 18 h / 80 °C
With
copper(I) oxide; hydrogenchloride; n-butyllithium; water; potassium carbonate; triethylamine; phenylboronic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: water; sodium dithionite / ethanol / 60 °C
2.1: triethylamine / ethyl acetate / 2 h / 90 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C
4.1: n-butyllithium / diethyl ether / -78 °C / Inert atmosphere
4.2: 1 h / -78 °C
4.3: pH 7
5.1: potassium carbonate / acetonitrile / 5 h / 20 °C
6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere
7.1: hydrogenchloride; water; phenylboronic acid / 16 h / 80 °C
8.1: copper(I) oxide / methanol / 18 h / 80 °C
With
copper(I) oxide; hydrogenchloride; n-butyllithium; sodium dithionite; water; potassium carbonate; triethylamine; phenylboronic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; methanol; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
