C₆₀H₄₉N₅O₉Se

Base Information

• Chemical Name: C₆₀H₄₉N₅O₉Se
• CAS No.: 422319-54-8
• Molecular Formula: C₆₀H₄₉N₅O₉Se
• Molecular Weight: 1063.04
• Mol file: 422319-54-8.mol

Synonyms:C₆₀H₄₉N₅O₉Se

Chemical Property of C₆₀H₄₉N₅O₉Se

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₄₉N₅O₉Se

There total 13 articles about C₆₀H₄₉N₅O₉Se which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine (312746-41-1) + C36H30N4O6 (422319-53-7) → C60H49N5O9Se (422319-54-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/ol017215d DOI:10.1021/jo0264980

Reference yield:

methyl (αR,2S)-2,3-dihydro-2-methyl-3-oxo-1-[(phenylmethoxy)carbonyl]-α-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1H-imidazo(1,2-a)indole-9-propanoate (316828-33-8) → C60H49N5O9Se (422319-54-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 23 percent / 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide / CH₂Cl₂ / 12 h / 20 °C

2.1: 81 percent / NaBH₄; AcOH / 2 h / 25 °C

3.1: H₂ / 5percent Pd/C / methanol / 0.5 h / 20 °C / 760.05 Torr

4.1: 108 mg / SiO₂ / CH₂Cl₂ / 12 h / 20 °C

5.1: 94 percent / (i-Pr)2NEt / CH₂Cl₂ / 12 h / 20 °C

6.1: Zn; CH₃COOH / ethyl acetate / 0.5 h / 20 °C

6.2: 84 percent / EDAC / acetonitrile / 0.33 h / 20 °C

7.1: 91 percent / EDAC / acetonitrile / 1 h / 20 °C

With sodium tetrahydroborate; 7b-Bu-7bH-oxaziridino[2,3-b][1,2]benzisothiazole-3,3-dioxide; hydrogen; silica gel; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; 5percent Pd/C; In methanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1021/jo0264980

Reference yield:

methyl (2S,9R,9aS,αR)-9-hydroxy-α-[[(2,2,2-trichloroethoxy)carbonyl]amino]-2-methyl-3-oxo-1-[(phenylmethoxy)carbonyl]-2,3,9,9a-tetrahydro-1H-imidazo(1,2-a)indole-9-propanoate (422319-39-9) → C60H49N5O9Se (422319-54-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: H₂ / 5percent Pd/C / methanol / 0.5 h / 20 °C / 760.05 Torr

2.1: 108 mg / SiO₂ / CH₂Cl₂ / 12 h / 20 °C

3.1: 94 percent / (i-Pr)2NEt / CH₂Cl₂ / 12 h / 20 °C

4.1: Zn; CH₃COOH / ethyl acetate / 0.5 h / 20 °C

4.2: 84 percent / EDAC / acetonitrile / 0.33 h / 20 °C

5.1: 91 percent / EDAC / acetonitrile / 1 h / 20 °C

With hydrogen; silica gel; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; 5percent Pd/C; In methanol; dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1021/jo0264980

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-L-β-phenylselenocysteine

C₃₆H₃₀N₄O₆

(R)-(+)-tryptophan methyl ester hydrochloride

N_α-2,2,2-trichloroethoxycarbonyl-D-tryptophan methyl ester