2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate

Base Information

• Chemical Name: 2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate
• CAS No.: 912635-61-1
• Molecular Formula: C₁₅H₁₇NO₄
• Molecular Weight: 275.304
• Mol file: 912635-61-1.mol

Synonyms:2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate

Chemical Property of 2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate

There total 1 articles about 2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-benzyl-3-pyrrolidinone (775-16-6) + oxalic acid diethyl ester (95-92-1) → 2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate (912635-61-1)

Guidance literature:

With sodium; In ethanol; at -10 - 20 ℃;

Reference yield:

2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate (912635-61-1) → 1,4,5,6-tetrahydropyrrole[3,4-c]pyrazole-yl-3-carboxylic acid ethyl ester (912635-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; hydrazine hydrate / 3 h / 0 °C / Reflux

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

2-(1-benzyl-4-oxopyrrolidin-3-yl)ethyl glyoxylate (912635-61-1) → C6H7N3O2

Guidance literature:

Multi-step reaction with 3 steps

1: H₂NNH₂

2: Alkaline hydrolysis

With hydrazine;

DOI:10.1016/j.bmcl.2007.06.028

upstream raw materials:

N-benzyl-3-pyrrolidinone

oxalic acid diethyl ester

Downstream raw materials:

C₁₃H₁₃N₃O₂

1,4,5,6-tetrahydropyrrole[3,4-c]pyrazole-yl-3-carboxylic acid ethyl ester