(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

Base Information

Chemical Name:(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester
CAS No.:101031-22-5
Molecular Formula:C₂₂H₂₆N₂O₆
Molecular Weight:414.458
Hs Code.:

Synonyms:(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

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Chemical Property of (S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

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Technology Process of (S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

There total 3 articles about (S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90417-31-5
ethyl-(5-cyano-3-pyridyl)carboxylate

: 101031-22-5
(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / acetyl chloride / CHCl₃; ethanol / 1.) 0 deg C, 1 h; 2.) up to RT, 12 h

2: 76 percent / Et₃N / 1,2-dichloro-ethane / 12 h / Heating

3: 1.) THF, -78 deg C, 5 h; 2.) -78 deg C

With triethylamine; acetyl chloride; In ethanol; chloroform; 1,2-dichloro-ethane;
DOI:10.1021/ja00268a043

Reference yield:

: 101031-17-8
ethyl <5-(ethoxycarbonyl)-3-pyridyl>imidate dihydrochloride

: 101031-22-5
(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Et₃N / 1,2-dichloro-ethane / 12 h / Heating

2: 1.) THF, -78 deg C, 5 h; 2.) -78 deg C

With triethylamine; In 1,2-dichloro-ethane;
DOI:10.1021/ja00268a043

Reference yield:

: 917-54-4
methyllithium

: 101031-18-9
2-<5-(ethoxycarbonyl)-3-pyridyl>-4(S)-methoxymethyl-5(S)-phenyl-Δ²-oxazoline

: 79-22-1
methyl chloroformate

: 101031-22-5
(S)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

: 101031-21-4
(R)-5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-4-methyl-4H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 deg C, 5 h; 2.) -78 deg C;
DOI:10.1021/ja00268a043