1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

Base Information

Chemical Name:1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine
CAS No.:1414778-52-1
Molecular Formula:C₁₉H₂₁F₃N₂O₂S
Molecular Weight:398.449
Hs Code.:

Synonyms:1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

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Chemical Property of 1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

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Technology Process of 1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

There total 5 articles about 1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1414778-70-3
C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine

: 386704-12-7,872626-76-1
6-(trifluoromethyl)pyridine-3-carbaldehyde

: 1414778-52-1
1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

Guidance literature:: C-cyclopropyl-C-(3-ethanesulfonylphenyl)methylamine; 6-(trifluoromethyl)pyridine-3-carbaldehyde; With magnesium sulfate; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In 1,2-dichloro-ethane; Product distribution / selectivity;

Reference yield:

: 3-ethylthiobenzaldehyde

: 1414778-52-1
1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 80 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: magnesium sulfate / 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 3 h / 20 °C

With diphenylphosphoranyl azide; hydrogen; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1414778-48-5
cyclopropyl[3-(ethylsulfonyl)phenyl]methanol

: 1414778-52-1
1-cyclopropyl-1-[3-(ethylsulfonyl)phenyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}methanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 80 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: magnesium sulfate / 1,2-dichloro-ethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C

With diphenylphosphoranyl azide; hydrogen; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In methanol; 1,2-dichloro-ethane; toluene;