2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

Base Information

Chemical Name:2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid
CAS No.:1430231-74-5
Molecular Formula:C₃₀H₃₂O₈S
Molecular Weight:552.645
Hs Code.:

Synonyms:2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

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Chemical Property of 2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

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Technology Process of 2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

There total 14 articles about 2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1432045-89-0
C₃₁H₃₄O₈S

: 1430231-74-5
2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.1016/j.bmcl.2013.03.060

Reference yield:

: 2-((8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

: 1430231-74-5
2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: With acetic acid; In ethanol; Resolution of racemate; Inert atmosphere;

Reference yield:

: 1000413-84-2
2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde

: 1430231-74-5
2-((3R,8S)-3-(2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)-2,3,7,8-tetrahydrobenzofuro[5,6-b][1,4]dioxin-8-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1,4-dioxane; water / 12 h / 100 °C

2: AD-mix-α / water; tert-butyl alcohol / 4 h / 0 - 20 °C

3: 1H-imidazole; dmap / N,N-dimethyl-formamide / 1 h / 20 °C

4: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 1 h / 50 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: palladium diacetate; 1,1'-[(1S)-(1,1'-binaphthalene)-2,2'-diyl]bis[1,1-di-tert-butyl-phosphine]; caesium carbonate / toluene / 12 h / 50 °C

7: sodium hydroxide; methanol / tetrahydrofuran / 1 h / 60 °C

With 1H-imidazole; methanol; dmap; tributylphosphine; AD-mix-α; 1,1'-[(1S)-(1,1'-binaphthalene)-2,2'-diyl]bis[1,1-di-tert-butyl-phosphine]; tetrabutyl ammonium fluoride; palladium diacetate; caesium carbonate; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 1: |Wittig Olefination / 2: |Sharpless Dihydroxylation / 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.03.060