2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

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Chemical Name:2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide
CAS No.:1567838-15-6
Molecular Formula:C₂₃H₁₆F₂N₄O₃S₂
Molecular Weight:498.534
Hs Code.:

Synonyms:2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

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Chemical Property of 2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

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Technology Process of 2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

There total 5 articles about 2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1567838-14-5
5-(5-(5-aminopyridin-3-yl)thiazol-2-yl)-2-methylisoindolin-1-one

: 13918-92-8
2,4-difluorobenzene-1-sulfonyl chloride

: 1567838-15-6
2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 - 45 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.12.057

Reference yield: 16.0%

: 1567838-15-6
2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 - 45 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1002309-19-4
2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoindolin-1-one

: 1567838-15-6
2,4-difluoro-N-(5-(2-(2-methyl-1-oxoisoindolin-5-yl)thiazol-5-yl)pyridin-3-yl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol / Inert atmosphere; Reflux

2: N-iodo-succinimide / chloroform; acetic acid / 20 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol / Inert atmosphere; Reflux

4: pyridine / dichloromethane / 20 h / 20 - 45 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; sodium carbonate; In ethanol; dichloromethane; chloroform; acetic acid; toluene; 1: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2016.12.057