6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine
• CAS No.: 1435615-02-3
• Molecular Formula: C₁₇H₁₉N₅
• Molecular Weight: 293.371
• Mol file: 1435615-02-3.mol

Synonyms:6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine

Chemical Property of 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine

There total 2 articles about 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

→ 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine (1435615-02-3)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 105 ℃; for 0.5h; Inert atmosphere;

Reference yield:

6-bromo-pyrazolo[1,5-α]pyrimidine (705263-10-1) + 1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine (747413-21-4) → 6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine (1435615-02-3)

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.03.113

Reference yield:

6-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidine (1435615-02-3) → C17H18IN5 (1435615-14-7)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 40h;

DOI:10.1016/j.bmcl.2013.03.113

upstream raw materials:

6-bromo-pyrazolo[1,5-α]pyrimidine

1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine

Downstream raw materials:

C₂₅H₂₃N₅S

C₂₃H₂₃N₅

C₂₂H₂₁ClN₆

C₂₆H₂₄N₆