1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose

Base Information

• Chemical Name: 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose
• CAS No.: 479035-81-9
• Molecular Formula: C₁₄H₁₄F₂O₅
• Molecular Weight: 300.259
• Mol file: 479035-81-9.mol

Synonyms:1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose

Chemical Property of 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose

There total 1 articles about 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + Benzoic acid (R)-3,3-difluoro-5-hydroxy-tetrahydro-furan-2-ylmethyl ester → 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose (479035-81-9)

Guidance literature:

With sulfuric acid; acetic acid; at 20 ℃; for 0.5h;

DOI:10.1021/jm040027j

Reference yield: 45.0%

N-(5-Fluoro-2-trimethylsilanyloxy-pyrimidin-4-yl)-benzamide (149712-92-5) + 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose (479035-81-9) → 5-fluoro-N4-benzoyl-1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-β-D-ribofuranosyl)cytosine (698391-74-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jm040027j

Reference yield:

O,O'-bis-(trimethylsilyl)uracil (10457-14-4) + 1-acetyl-5-O-benzoyl-2,3-dideoxy-3,3-difluoro-D-ribofuranose (479035-81-9) → 1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-α/β-D-ribofuranosyl)uracil (698391-72-9)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jm040027j

upstream raw materials:

acetic anhydride

Downstream raw materials:

N⁴-benzoyl-1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-β-D-ribofuranosyl)cytosine

N⁴-benzoyl-1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-α-D-ribofuranosyl)cytosine

5-fluoro-N⁴-benzoyl-1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-β-D-ribofuranosyl)cytosine

1-(5-O-benzoyl-2,3-dideoxy-3,3-difluoro-α/β-D-ribofuranosyl)uracil