N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

Base Information

Chemical Name:N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide
CAS No.:1431284-66-0
Molecular Formula:C₂₄H₂₃Cl₂FN₄O
Molecular Weight:473.377
Hs Code.:

Synonyms:N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

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Chemical Property of N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

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Technology Process of N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

There total 4 articles about N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1305350-71-3
(R)-N-(pyrrolidine-3-yl)cyclopropanecarboxamidehydrochloride

: 1431285-44-7
1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxaldehyde

: 1431284-66-0
N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

Guidance literature:: (R)-N-(pyrrolidine-3-yl)cyclopropanecarboxamidehydrochloride; 1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxaldehyde; In dichloromethane; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 18h;

Reference yield:

: 1431285-43-6
N-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl]cyclopropanecarboxamide

: 1431284-66-0
N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate; 5%-palladium/activated carbon / ethanol; water / 3 h / Inert atmosphere; Reflux

2.1: dichloromethane / 1 h

2.2: 18 h

With 5%-palladium/activated carbon; ammonium formate; In ethanol; dichloromethane; water;

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1431284-66-0
N-[(3S)-1-[[1-(3,4-dichlorophenyl)-3-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl]-3-pyrrolidinyl] cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / ethanol / 0.08 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1,3,5-trichloro-2,4,6-triazine / 18 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 1 h

3.2: 18 h

With 1,3,5-trichloro-2,4,6-triazine; sodium acetate; In ethanol; dichloromethane;