1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline

Base Information

• Chemical Name: 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline
• CAS No.: 153718-75-3
• Molecular Formula: C₁₉H₂₀N₂O₄S
• Molecular Weight: 372.445
• Mol file: 153718-75-3.mol

Synonyms:1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline

Chemical Property of 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline

There total 12 articles about 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7,8-Dimethoxy-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinoline-5-carboxylic acid tert-butyl ester (184957-88-8) → 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline (153718-75-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/jo961743z

Reference yield:

Toluene-4-sulfonic acid 2-[6,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl ester (153718-68-4) → 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline (153718-75-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / AcONO₂, Ac₂O / 2 h / -45 - -20 °C

2: H₂ / PtO₂ / ethanol / 0.5 h

3: N,N-diisopropylethylamine / CHCl₃ / 1.) 60 deg C, 29 h, 2.) reflux, 24 h

With nitro acetate; hydrogen; acetic anhydride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; chloroform;

DOI:10.1021/ja00084a026

Reference yield:

1-N-(p-tolylsulfonyl)-3-<2-p-<(tolylsulfonyl)oxy>ethyl>-4-nitro-6,7-dimethoxyindole (153718-72-0) → 1,3,4,5-tetrahydro-7,8-dimethoxy-1-(4-methylbenzenesulfonyl)pyrrolo<4,3,2-de>quinoline (153718-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / ethanol / 0.5 h

2: N,N-diisopropylethylamine / CHCl₃ / 1.) 60 deg C, 29 h, 2.) reflux, 24 h

With hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In ethanol; chloroform;

DOI:10.1021/ja00084a026

upstream raw materials:

Toluene-4-sulfonic acid 2-[4-amino-6,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl ester

7,8-Dimethoxy-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinoline-5-carboxylic acid tert-butyl ester

6,7-dimethoxy-4-methylquinoline

1,3,4,5-tetrahydro-7,8-dimethoxypyrrolo<4,3,2-de>quinoline

Downstream raw materials:

7-Methoxy-1-<(4-methylphenyl)sulfonyl>-3,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one