(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester
CAS No.:160230-47-7
Molecular Formula:C₂₇H₃₉N₃O₆S
Molecular Weight:533.689
Hs Code.:

Synonyms:(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

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Chemical Property of (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

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Technology Process of (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

There total 4 articles about (1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.56%

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 160232-08-6
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

: 160230-47-7,2126144-72-5
(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at 25 - 35 ℃; for 2h;

Reference yield:

: 72225-62-8
N-(4-Isobutylsulfamoyl-phenyl)-acetamide

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 160230-47-7,2126144-72-5
(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In 1,4-dioxane; at 85 - 90 ℃; for 14h;

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 160230-47-7,2126144-72-5
(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl-(4-acetylaminobenzenesulfonyl amino)propyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: neat (no solvent) / 2 h / 50 - 60 °C / Reflux

2: triethylamine / dichloromethane / 1 h / 0 - 30 °C

With triethylamine; In dichloromethane;