4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid
CAS No.:1426329-93-2
Molecular Formula:C₃₀H₂₉NO₆
Molecular Weight:499.563
Hs Code.:

Synonyms:4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

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Chemical Property of 4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

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Technology Process of 4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

There total 7 articles about 4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1426329-92-1
benzyl 4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

: 1426329-93-2
4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: With palladium on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 7h;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 153624-46-5
4-(isopropoxy)phenylboronic acid

: 1426329-93-2
4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 14 h / Reflux; Inert atmosphere

2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 15 h / 85 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C

6.1: palladium on carbon; hydrogen / ethyl acetate / 7 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-89-6
benzyl N-benzenesulfonyl-3-bromo-4-(4-isopropoxyphenyl)pyrrole-2-carboxylate

: 1426329-93-2
4-(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 15 h / 85 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C

4: palladium on carbon; hydrogen / ethyl acetate / 7 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077